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Meetings Held in 2012

Please note: We do not make public any information about our current year's program.

01-2_copyStudents at work February 10-15
Communicating Science

Funded by:
The Boehringer Ingelheim Fonds Foundation for Basic Research in Medicine, Heidesheim, Germany

Organized By:
S. Schedler, Boehringer Ingelheim Fonds, Heidesheim, Germany
C. Walther, Boehringer Ingelheim Fonds, Heidesheim, Germany

A scientist running a laboratory is essentially a running a business, small to begin with but likely to get larger with time. And so scientists need to develop skills akin to those needed to run a business–identifying and resolving conflicts; dealing with difficult people; leading effective and productive meetings; and communicating effectively within the laboratory and with the outside world. These skills, if acquired at all, are usually learned haphazardly, after the fact. How much better to learn them systematically and in advance of needing them!

March 16-18
Leading Science Workshop

Funded by:
The American Express Foundation, New York, New York

Organized By:
C.M. Cohen, Science Management Associates, Newton, Massachusetts
D. Kennedy, Worklab Consulting LLC, New York
This workshop, the second in a series supported by the American Express Foundation, brought together life scientists making, or recently having made, the transition to a leadership or managerial position in academia, not-for-profit organizations, or the private sector. It focused on the techniques, situations, and challenges that relate specifically to leading and managing in the scien­tific workplace. Participants were able to share their experiences and challenges with one another and to receive feedback and guidance from others with similar experience. The workshop helped participants identify areas where they needed guidance, as well as how to capitalize on areas of strength. Participants learned and developed the necessary skills to lead and interact effectively with others in both one-on-one and group settings.

H. Zogbhi
March 16-18
The 4th NIMH Sponsored Brain Camp

Funded by:
National Institute of Mental Health

Organized By:
Thomas Insel, NIMH, Bethesda,Maryland
Mayada Akil, NIMH, Bethesda,Maryland 
Once again, we were delighted to host the National Institute of Mental Health (NIMH)-sponsored “Brain Camp.” The goal of the Brain Camp is to identify areas of neuroscience that are of interest and relevance to psychiatrists and to communicate these to a small group of outstanding psychiatry residents and research fellows. Some of the most distinguished and thoughtful neuroscientists in the country came as guest speakers to the meeting. The goal of the series of meetings is to develop a neuroscience curriculum that can eventually be shared with psychiatry training programs around the country.

04-2_copy C. DeRosa, H. Mille April 1-3
Envisioning the Future of Science Libraries at Academic Research Institutions

Funded by:
The Alfred P. Sloan Foundation
The Rockefeller University, New York, New York

Organized By:
J C. Feltes, The Rockefeller University, New York
D. Gibson, Memorial Sloan-Kettering Cancer Center, New York
C. Norton, Marine Biological Laboratory, Woods Hole, Massachusetts
L. Pollock, Cold Spring Harbor Laboratory  

As a result of social, economic, and technological factors, the role of libraries in society and aca­demia is changing rapidly and significantly. As key service providers, libraries are expected to be up-to-date technologically and to adapt to changing circumstances and the changing needs of their users. This is particularly true of libraries catering to scientists where the changes in science publishing have been remarkable, and where the users are more likely to expect the latest tech­nologies. This has been a source of conflict, uncertainty, and concern at many institutions. For this reason, this meeting brought together librarians, researchers, administrators, and experts in various topics relating to future developments in library science to discuss the future of science libraries at academic research institutions.

K. Adelman
April 9-12
Transcription and Cancer

Funded by:
Cold Harbor Laboratory Corporate Sponsor Program

Organized By:
J. Bradner, Dana-Farber Cancer Institute, Boston, Massachusetts
R. Young, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts

Genetic alterations that alter signaling, transcription, and chro­matin are hallmarks of cancer. New insights in transcriptional and chromatin biology, coupled with technical advances in dis­covery chemistry, have allowed unprecedented progress toward therapeutics that target this traditionally undruggable class of proteins. Motivated by the historic and pressing challenge of developing direct-acting inhibitors of gene regulatory complex­es, participants in this meeting included leaders in the fields of transcriptional biology, chromatin biology, protein biochemis­try, and cancer drug discovery.

06-2_copy E. Ching, S. Subramani April 15-17
Phage and Phage-Based Therapies

Funded by:
GangaGen, Inc., Newark, California

Organized By:
S. Adhya, National Cancer Institute, Bethesda, Maryland
J. Ramachandran, GangaGen Inc., Palo Alto, California
G. Schoolnik, Stanford University Medical Center, Palo Alto, California

The first Banbury conference on phage therapy was held in November 2002. Since that discussion of the potential value of phage therapy and the challenges it faced, there has been much progress in both phage science and the development of phage-based therapies. As more and more pathogens are developing resistance to the current antibiotics, there is a pressing and ever increasing need for new therapies. This second conference on Phage Therapy was organized to review the progress in phage science, the preclinical development of phage-based therapies and clinical experience. .

07-1_copyParticipants April 19-21
Interdisciplinary Symposium on Literature, Memory, and Neuroscience

Funded by:
Haig R. Nalbantian, New York, New York
The Satenik and Adom Ourian Educational Foundation, New York, New York
Mr. and Mrs. Howard Phipps, Jr., Westbury, New York
The Daniel and Joanna S. Rose Fund, Inc., New York, New York

Organized By:
S. Nalbantian, Long Island University, Brookville, New York

It is now more than 50 years since C.P. Snow gave his controversial Reith Lectures on The Two Cultures, discussing the gulf, as Snow saw it, between the humanities and science. Snow was mak­ing specific reference to the British education system, but the phrase soon came into wide spread use. This meeting, held under the auspices of the International Comparative Literature Associa­tion, might be regarded as a contribution to uniting the two cultures. Its purpose was to create cross-disciplinary exchange and collaboration between neuroscientists and literary scholars on topics of memory, emotion, consciousness, and creativity .

08-2_copy T. Rea April 22-25
Patenting Genes: New Developments, New Questions

Funded by:
Baxter Healthcare Corporation, DRI Capital, Inc., Eli Lilly & Company
Genentech, Inc., Jones Day LLP Kaye Scholer LLP King & Spalding, LLP
Novartis Pharma AG,Novo Nordisk Inc. Ropes & Gray  

Organized By:
K. Sonnenfeld, King & Spalding, LLP, New York
M. Brivanlou, King & Spalding, LLP, New York

In 1981, more than 30 years ago and soon after the Supreme Court’s decision in Diamond v. Chakrabarty, the Banbury Center held a discussion meeting called Patenting of Life Forms. A second meeting in 1991 was held, and now, 20 years later, many of those very same issues raised at these two meetings continue to be contentious and the subject of intense debate. They have been brought into sharp focus by the recent Myriad case involving patents covering the BRCA gene and so it seemed the right time to convene a third meeting. By bringing together lawyers, judges, clinicians, scientists, academicians, investors, and others who are directly impacted by gene patents, the conference provided a unique opportunity to examine fundamental assumptions that have provided fuel on both sides of the debate for or against gene patents .

09-3_copyJ. Witkowski May 3-5
A History of the Human Genome Project

Funded by:
The Alfred P. Sloan Foundation, New York, New York

Organized By:
L. Pollock, Cold Spring Harbor Laboratory
J.A. Witkowski, Cold Spring Harbor Laboratory

The International Human Genome Project (HGP) was one of the great scientific accomplishments, ranking with the Manhattan Project, the Hubble Telescope, and the Large Hadron Collider. However, it is only during the past few years that a movement has begun to lay the ground­work for a history of the HGP. As a first step, CSHL and the Wellcome Trust initiated a project to locate and catalog primary materials relating to the origins of the HGP by holding a meeting at Banbury in 2009. This 2012 meeting reviewed the current state of the HGP history proj­ect and plans for producing a book on the HGP, what might be needed for a long-term project, and the goals and organization of long-term projects. Participants included scientists, writers, documentary direc­tors, social scientists, media experts, historians, and archivists .

10-4_copyR. Kalluri, J. Watson May 14-17
Regulation of Metabolism in Cancer

Funded by:
Brown Cancer Center, University of Louisville, Kentucky

Organized By:
J. Chesney, University of Louisville, Louisville, Kentucky
J.D. Watson, Cold Spring Harbor Laboratory
Genetic and epigenetic alterations of transformed cells confer selective advantages that ultimately change their metabolic phenotype. For example, transformed cells transport increased glucose for energetic and anabolic pathways. Approaches to in­tegrate the metabolic with the genomic, epigenetic, and tran­scriptional alterations of cancer should lead to the identification of novel cancer therapeutic targets. The main objectives of this meeting were to discuss (1) the biophysical and biochemical studies of the unique metabolic requirements and pathway utilizations of transformed cells, (2) emerging sequencing and computational technologies that can rapidly analyze cancer ge­nomes and transcriptional profiles, and (3) biomedical infor­matics and physical approaches to integrating the metabolic, genomic, and transcriptional interactions of cancer.

S. Hingorani
June 13-15
Emerging Approaches in Oncology: A Brainstorming Think Tank

Funded by:
University of Southern California, NCI Physical Sciences in Oncology Center, Los Angeles

Organized By:
D. Hillis, Applied Minds, Inc. Glendale, California
D. Agus, University of Southern California, Los Angeles
P. Mallick, Stanford School of Medicine, California
T. Tombrello, California Institute of Technology, Pasadena
The goal of this meeting was to identify critical challenges in oncology and to evaluate the potential of innovative approaches for solving them. The meeting had a rather unusual structure for a Banbury Center meeting. Prior to the meeting, each participant was assigned to two groups (biological/clinical or technology/engineering) and selected a collaborator from the other who could engage in the project. Unlike traditional meetings, in which people present their findings, it was hoped that this would be an opportunity for participants to share emerging research challenges and to identify and evaluate creative approaches for solving them. Team meetings were held in the Conference Room and Meier House, followed by joint sessions in the Conference Roo.

Jennifer Darnell
September 9-12
Systems Biology of Autism: From Basic Science to Therapeutic Strategies

Funded by:
Marie Robertson Research Fund, Cold Spring Harbor Laboratory, New York
Robertson Fund, Cold Spring Harbor Laboratory, New York
Pfizer Inc., Memphis, Tennessee
Simons Foundation, New York, New York
Certerra, Inc., Cold Spring Harbor, New York

Organized By:
P. Osten, Cold Spring Harbor Laboratory
M. Sur, Massachusetts Institute of Technology, Cambridge
Genetic analyses of autism have identified a confusingly large number of genes associated with autism. One way of trying to bring some order to the field is to try to group these genes based on common pathways. A combination of different systems biology methods (mouse and other animal models, human iPS cells, genetics, and bioinformatics) could result in a powerful research synergy and lead to a formulation of generalizable hypotheses about neurodevelopmental changes in autism. This meeting explored whether this was feasible. Ultimately, the goal of such research must be to develop therapies, and this requires deciding on what experimental endophenotypes will provide the most useful platforms for drug discovery. Participants included scientists studying autism genes in animal models and using human iPS cells for screening of cellular functions; geneticists and bioinformaticists; representatives from pharmaceutical companies interested in autism drug development; and systems neuroscientists.

J. Watson, C. Van Veenendaal,
A. Trounson
September 14-16

Funded by:
Inspire2Live, Utrecht, Netherlands

Organized By:
Inspire2Live Discovery Network Team (Amsterdam, Cambridge, Oxford, Paris, New York, Boston, Seattle)
The Inspire2Live Foundation was created with the aim of motivating as many people as possible to constantly challenge and expand their boundaries and to raise funds to fight cancer by organizing fund-raising events. The Foundation has shifted its funding strategy toward mobilizing a team of committed sponsors. To this end, the presidents of the Alp d’HuZes fund raiser and the Dutch Cancer Foundation KWF came to Banbury Center together with senior members of the cancer research community. The meeting began with updates on the scientific research of the Foundation’s program, followed by presentations on the clinical aspects of the program. Discussion then turned to the Foundation’s funding plans, followed by a detailed focus on setting up the organizational necessities needed in 2012 in preparation for 2013.

O. Danilevskaya,  D. Jackson
September 18-21
Plant–Environment Interactions

Funded by:
Cold Spring Harbor/Pioneer DuPont Joint Collaborative Project

Organized By:
M. Timmermans, Cold Spring Harbor Laboratory
M. Komatsu, DuPont Pioneer, Wilmington, Delaware
R. Martienssen, Cold Spring Harbor Laboratory
S. Tingey, DuPont Pioneer, Wilmington, Delaware
The goals of this meeting were to review the latest advances in our understanding of the plant’s responses to abiotic environmental cues and pathogens, and during the establishment of symbiotic associations. These reviews were expected to drive discussions on current research addressing natural variation and adaptation to biotic and abiotic stresses. The meeting included, in addition to members of the CSHL/DuPont Pioneer Joint Collaborative, speakers from outside the collaboration .

M. Cooperstock, S. Vernon,
L. Bateman, K. Rowe
September 30−October 3
Decoding Clinical Trials to Improve Treatment of ME/CFS

Funded by:
The Cold Spring Harbor Laboratory Corporate Sponsor Program

Organized By:
CFIDS Association of America, Charlotte, North Carolina
Centers for Disease Control and Prevention, Atlanta, Georgia

In the past few years, sequencing instrument capabilities have increased more than 1000 fold and are likely to continue to increase about five-fold each year for the next several years. However, analysis methods have not improved nearly as much during the same time period and a variety of technical limitations of these new instruments make it even more difficult to carry out whole genome sequencing of novel genomes (de novo sequencing). The goals of this meeting were to assess the current state of de novo sequencing, predict what can be expected to develop in the near future, and determine how these exciting technologies could be used to carry out de novo sequencing of entire complex plant genomes.

T. Daniel, W. Zamer
November 8-11
Grand Challenges in Organismal Biology

Funded by:
National Science Foundation through a grant to Stony Brook University

Organized By:
D. Padilla, Stony Brook University, New York
B. Swalla, University of Washington, Seattle
B. Tsukimura, California State University, Fresno
The National Research Foundation has established Research Coordination Networks (RCNs) in various fields, intended to “. . .advance a field or create new directions in research or education by supporting groups of investigators to communicate and coordinate their research, training, and educational activities across disciplinary, organizational, geographic, and international boundaries.” Investigators came to Banbury to consider the potential value of an RCN for metazoan organismal biology, specifically the issue “How organisms walk the tightrope between stability and change” and, more broadly, “What will be needed as far as infrastructure to solve complex problems and interactions across scales?” One of the goals of the meeting was to plan a full-scale workshop on the topic .

J. Haley
November 6-9
Cell Plasticity in Cancer Evolution

Funded by:
Astellas-OSI Oncology, Farmingdale, New York

Organized By:
J. Condeelis, Albert Einstein College of Medicine, Bronx, New York
D. Epstein, Astellas-OSI Oncology, Farmingdale, New York
J. Haley, Astellas-OSI Oncology, Farmingdale, New York
Banbury Center has been the location for several meetings on the epithelial-mesenchymal transition (EMT) in cancer. This is the most studied form of cellular plasticity and is characterized by the combined loss of epithelial cell junction proteins and cell polarity and the gain of mesenchymal markers. More recently, EMTs have been characterized where the interconversion of vessels and fibroblastic elements can contribute to cancer pathogenesis and fibrosis. These findings have important implications for cancer treatment and prevention. For example, cellular sensitivity to multiple targeted therapies, chemotherapy, and radiotherapy was shown to be governed by the extent to which cells have undergone an EMT-like transition. Resistance associated with cellular plasticity and heterogeneity has been observed in multiple systems derived from adenocarcinomas and squamous carcinomas. The aim of this conference was to explore the molecular and pathobiological significance of cellular plasticity in carcinomas and to the elucidation of signaling pathways which promote plasticity .

18-2_copy M. Saleh November 26-29
Inflammation, Cancer, and Metabolism

Funded by:
Cold Spring Harbor Laboratory Corporate Sponsor Program

Organized By:
D. Green, St. Jude Children’s Hospital, Memphis, Tennessee
L. O’Neill, Trinity College, Dublin, Ireland
Otto Warburg showed that tumor cells performed aerobic glycolysis and proposed that this metabolic change was fundamental for pathogenesis of cancer. Mutations in important metabolic enzymes have been shown to be important for tumorigenesis, and more recently, molecular insights into the basis of the Warburg effect have emerged, including the roles of the transcription factor HIF-1α and also enzymes such as PKM2. Immunologists have also recently turned their attention to changes in immune cell function, and the Warburg effect is now known to occur in activated macrophages and certain T-cell lineages. Other metabolic processes, including those involving AMP kinase and mTOR, are also now seen as important for the immune and inflammatory processes. A number of questions arise. Why are these metabolic changes occurring and what is their mechanistic basis? Might changes in metabolism during cancer and inflammation be critical for disease development? Might these metabolic changes provide an explanation for the link between inflammation and cancer? Is there a prospect here that new treatments might emerge from these insights?