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Neuroscience

NeuroscienceCSHL neuroscientists focus on understanding how neural activity and neural circuitry underlie behavior, and how disruptions in these circuits lead to neurological and neuropsychiatric disorders such as Alzheimer's disease, autism, schizophrenia and depression. These questions are addressed in two model systems—rodents and Drosophila—using molecular, cellular, genetic, developmental, theoretical, physiological and behavioral approaches.

Neuroscience research at CSHL is highly collaborative, and can be divided into three broad themes: sensory processing, cognition, and cognitive disorders.  The sensory processing group addresses basic questions about sensory representations (auditory, olfactory and visual) and decision-making. The cognition group uses the tools of modern neuroscience (genetic, molecular, physiology and imaging) to study the neural mechanisms underlying cognitive processes—including attention, memory and decision-making—that have traditionally been studied only in nonhuman and human primate models.  The cognitive disorder group builds on recent findings about the genetic basis of diseases like autism and schizophrenia to define how neural circuits and synaptic function are disrupted in these disorders. In addition, there is an effort to develop new anatomical methods to improve our understanding of brain circuits, connectivity and function.

  

Neuroscience researchers at CSHL:

Albeanu, Dinu Florin (Associate Professor)
Neuronal circuits; sensory coding and synaptic plasticity; neuronal correlates of behavior; olfactory processing

Churchland, Anne (Associate Professor)
Decision-making; electrophysiology; sensory processing; vision; audition; neural computation; modeling; behavior

Dubnau, Joshua (Associate Professor)
Learning; memory; genetics; behavior

Enikolopov, Grigori (Adjunct Professor)
Stem cells; neurogenesis; imaging; signal transduction

Furukawa, Hiro (Associate Professor)
Membrane proteins, X-ray crystallography, electrophysiology, neurodegenerative disease

Huang, Z. Josh (Professor)
Development and function of the GABAergic inhibitory circuitry in neocortex; cortical circuits; mouse genetics; developmental plasticity; neurogenomics; autism

Kepecs, Adam (Professor)
Decision-making; neural circuits; behavioral electrophysiology; theoretical neuroscience; neuroeconomics

Koulakov, Alexei (Professor)
Theoretical neurobiology; quantitative principles of cortical design; computer science; applied mathematics

Li, Bo (Associate Professor)
Synapse; physiology and plasticity; neural circuits; fear processing; reward processing; rodent behaviors related to mental disorders

Mitra, Partha P. (Professor)
Neuroscience and theoretical biology

Osten, Pavel (Associate Professor)
Neurobiology of autism and schizophrenia; gene expression-based mapping of brain activity; anatomical mapping of brain connectivity; high throughput microscopy

Shea, Stephen (Associate Professor)
Olfaction; audition; communication behaviors; in vivo electrophysiology; individual recognition

Tollkuhn, Jessica (Assistant Professor)
Transcriptional regulation; chromatin; critical periods in neurodevelopment; steroid hormones and behavior

Turner, Glenn (Adjunct Associate Professor)
Neural coding; learning and memory; sensory processing; Drosophila; electrophysiology

Van Aelst, Linda (Professor)
Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development and disorders

Zador, Anthony (Professor)
Neural circuits; sensory processing, attention and decision making; attention; molecular tool development; connectomics

Zhong, Yi (Adjunct Professor)
Neurophysiology; Drosophila; learning and memory; neurofibromatosis; signal transduction