CSHL Cancer Center - Gene Regulation & Cell Proliferation
The Gene Regulation & Cell Proliferation Program is an interdisciplinary effort focused on understanding the mechanisms that govern both normal and cancerous cell growth. The researchers in this program combine traditional experimental biology with cutting-edge technology to gain significant insights into DNA replication, epigenetics, and RNA biology.
Chakrabortty, S. K. and Prakash, A. and Nechooshtan, G. and Hearn, S. and Gingeras, T. R. (2015) Extracellular vesicle-mediated transfer of processed and functional RNY5 RNA. RNA 21(11) pp. 1966-1979.
Kinney, J. B. (2015) Unification of field theory and maximum entropy methods for learning probability densities. Physical Review E 92(3)
Bergmann, J. H. and Li, J. and Eckersley-Maslin, M. A. and Rigo, F. and Freier, S. M. and Spector, D. L. (2015) Regulation of the ESC transcriptome by nuclear long non-coding RNAs. Genome Res 25(9) pp. 1336-1346.
Burke, S. L. and Hammell, M. and Ambros, V. (2015) Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans. Genetics 200(4) pp. 1201-18.
Wasik, K. A. and Tam, O. H. and Knott, S. R. and Falciatori, I. and Hammell, M. and Vagin, V. V. and Hannon, G. J. (2015) RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Genes Dev 29(13) pp. 1403-1415.
Roe, Jae-Seok and Mercan, Fatih and Rivera, Keith and Pappin, Darryl J and Vakoc, Christopher R (2015) BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. Molecular Cell 58(6) pp. 1028-1036.
Akerman, M. and Fregoso, O. I. and Das, S. and Ruse, C. and Jensen, M. A. and Pappin, D. J. and Zhang, M. Q. and Krainer, A. R. (2015) Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol 16(1) pp. 119.
Shi, J. and Wang, E. and Milazzo, J. P. and Wang, Z. and Kinney, J. B. and Vakoc, C. R. (2015) Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nat Biotechnol 33(6) pp. 661-67.
Kara, N. and Hossain, M. and Prasanth, S. G. and Stillman, B. (2015) Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning During G1 Phase and Assembly of the Origin Recognition Complex in Human Cells. J Biol Chem 290(19) pp. 12355-12369.
Dos Santos, C. O. and Dolzhenko, E. and Hodges, E. and Smith, A. D. and Hannon, G. J. (2015) An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland. Cell Reports
Wang, E. and Kawaoka, S. and Roe, J. S. and Shi, J. and Hohmann, A. F. and Xu, Y. and Bhagwat, A. S. and Suzuki, Y. and Kinney, J. B. and Vakoc, C. R. (2015) The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer. Elife 4
Naguib, Adam and Bencze, Gyula and Cho, Hyejin and Zheng, Wu and Tocilj, Ante and Elkayam, Elad and Faehnle, Christopher R and Jaber, Nadia and Pratt, Christopher P and Chen, Muhan and Zong, Wei-Xing and Marks, Michael S and Joshua-Tor, Leemor and Pappin, Darryl J and Trotman, Lloyd C (2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell 58(2) pp. 255-268.
Hogan, Megan S and Parfitt, David-Emlyn and Zepeda-Mendoza, Cinthya J and Shen, Michael M and Spector, David L (2015) Transient Pairing of Homologous Oct4 Alleles Accompanies the Onset of Embryonic Stem Cell Differentiation. Cell Stem Cell 16(3) pp. 275-288.
Yu, J. R. and Tai, Y. and Jin, Y. and Hammell, M. C. and Wilkinson, J. E. and Roe, J. S. and Vakoc, C. R. and Van Aelst, L. (2015) TGF-beta/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev 29(3) pp. 250-61.
Kuhn, C. D. and Wilusz, J. E. and Zheng, Y. and Beal, P. A. and Joshua-Tor, L. (2015) On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme. Cell 160(4) pp. 644-658.
Pervouchine, D. D. and Djebali, S. and Breschi, A. and Davis, C. A. and Barja, P. P. and Dobin, A. and Tanzer, A. and Lagarde, J. and Zaleski, C. and See, L. H. and Fastuca, M. and Drenkow, J. and Wang, H. and Bussotti, G. and Pei, B. and Balasubramanian, S. and Monlong, J. and Harmanci, A. and Gerstein, M. and Beer, M. A. and Notredame, C. and Guigo, R. and Gingeras, T. R. (2015) Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression. Nat Commun 6pp. 5903.
Hua, Y. and Liu, Y. H. and Sahashi, K. and Rigo, F. and Bennett, C. F. and Krainer, A. R. (2015) Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models. Genes Dev 29(3) pp. 288-297.
Shen, C. and Vakoc, C. R. (2015) Gain-of-function mutations in chromatin regulators as a tumorigenic mechanism and opportunity for therapeutic intervention. Current Opinion in Oncology 27(1) pp. 57-63.
Boj, Sylvia F and Hwang, Chang-Il and Baker, Lindsey A and Chio, Iok In Christine and Engle, Dannielle D and Corbo, Vincenzo and Jager, Myrthe and Ponz-Sarvise, Mariano and Tiriac, Hervé and Spector, Mona S and Gracanin, Ana and Oni, Tobiloba and Yu, Kenneth H and van Boxtel, Ruben and Huch, Meritxell and Rivera, Keith D and Wilson, John P and Feigin, Michael E and Öhlund, Daniel and Handly-Santana, Abram and Ardito-Abraham, Christine M and Ludwig, Michael and Elyada, Ela and Alagesan, Brinda and Biffi, Giulia and Yordanov, Georgi N and Delcuze, Bethany and Creighton, Brianna and Wright, Kevin and Park, Youngkyu and Morsink, Folkert H M. and Molenaar, I. Quintus and Borel Rinkes, Inne H and Cuppen, Edwin and Hao, Yuan and Jin, Ying and Nijman, Isaac J and Iacobuzio-Donahue, Christine and Leach, Steven D and Pappin, Darryl J and Hammell, Molly and Klimstra, David S and Basturk, Olca and Hruban, Ralph H and Offerhaus, George Johan and Vries, Robert G J. and Clevers, Hans and Tuveson, David A (2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell 160(1-2) pp. 324-338.
Schuck, S. and Stenlund, A. (2015) A conserved regulatory module at the C-terminus of the papillomavirus E1 helicase domain controls E1 helicase assembly. Journal of Virology 89(2) pp. 1129-1142.Additional materials of the author at
CSHL Institutional Repository
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