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Cancer

Cancer

Cancer research at CSHL is devoted to understanding the fundamental biology of human cancer. This strong commitment to studying basic cellular processes is based on the premise that understanding how these processes are altered in cancer cells will ultimately provide a framework for rational therapies. Several technological advances developed at CSHL have given rise to innovative genomic approaches and the development of new mouse models of various cancer types. Together, these provide a powerful pathway for discovery, characterization and validation of genes that contribute to the development and progression of cancer.  A unique aspect of the CSHL cancer program is its interactive nature -- scientists are encouraged to share their ideas and work on questions in a synergistic way that far exceeds the power of any single laboratory working in isolation. The primary goal of the cancer program is likewise shared: to improve the diagnosis and treatment of all major forms of cancer.

CSHL is one of approximately 60 institutions supported by the Cancer Centers Program of the National Cancer Institute (NCI) and has been designated as an NCI Cancer Center since 1987. The CSHL Cancer Center is organized into three main program areas and includes 9 shared resources which support and enhance research efforts at CSHL. (More about the CSHL Cancer Center)

 

Cancer researchers at CSHL:

Atwal, Gurinder (Associate Professor)
Population genetics; bioinformatics; cancer; stochastic processes; statistical mechanics and information theory

Chang, Kenneth (Research Assistant Professor/Manager, Functional Genomics)

dos Santos, Camila (Assistant Professor)
Breast cancer, mammary gland development, stem cells, enhancer biology, gene regulation

Egeblad, Mikala (Associate Professor)
Tumor microenvironment; intravital imaging; tumor-associated myeloid cells; breast cancer

Fearon, Douglas (Professor)
Cancer immunology, pancreatic cancer, mouse models

Gingeras, Thomas (Professor)
Genome-wide organization of transcription and the functional roles of non-protein coding RNAs

Hammell, Christopher (Assistant Professor)
Post-transcriptional gene regulation; control of animal developmental timing; RNA biology

Hammell, Molly (Assistant Professor)
Gene regulatory networks; integrated genomic analysis; bioinformatics; RNA biology; small RNAs

Hannon, Gregory (Adjunct Professor & HHMI Investigator)
Growth control in mammalian cells; post-transcriptional gene silencing

Hicks, Jim (Research Professor)
Genomics; cancer genes;

Joshua-Tor, Leemor (Professor & HHMI Investigator)
Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography

Kinney, Justin (Assistant Professor)
Sequence-function relationships; machine learning; biophysics; transcriptional regulation

Krainer, Adrian R. (Professor)
Posttranscriptional control of gene expression; alternative splicing; splicing in genetic diseases and cancer; splicing-targeted antisense therapeutics

Krasnitz, Alexander (Associate Professor)
In silico genomics of cancer; single-cell genomics; inference from noisy biological data; large-scale numerical computing

Lee, Je H. (Assistant Professor)
Single-cell, in situ RNA-seq, non-coding RNA, spatial genomics, cancer microenvironment, pancreatic cancer

Levy, Dan (Assistant Professor)
Computational biology; human genetics; phylogenetics; copy number variation

Lyons, Scott (Research Assistant Professor/Manager, Animal Imaging)

Martienssen, Rob (Professor & HHMI Investigator)
Plant genetics; transposons; development; gene regulation; DNA methylation

McCombie, W. Richard (Professor)
Genomics of psychiatric disorders; genomics of cancer; computational genomics; plant genomics

Mills, Alea A. (Professor)
Cancer; development; aging; senescence; epigenetics

Pappin, Darryl (Research Professor)
Proteomics, mass spectrometry, protein chemistry

Powers, Scott (Research Professor)
Cancer genomics; functional genomics; cancer treatment

Schatz, Michael (Associate Professor)
Genomics; DNA sequencing; genome assembly & validation; sequence alignment; high performance and multicore computing; parallel algorithms; cloud computing

Sheltzer, Jason (CSHL Fellow)
Cancer genetics, aneuploidy, genome dosage imbalances, systems biology

Siepel, Adam (Professor)
Computational biology, population genetics, computational genomics, molecular evolution, gene regulation

Sordella, Raffaella (Associate Professor)
Molecular therapeutics; signal transduction

Spector, David L. (Professor & Director of Research)
Cell biology; gene expression; nuclear structure; microscopy; non-coding RNAs

Stenlund, Arne (Associate Professor)
Papillomavirus; cancer; DNA replication

Stillman, Bruce (President & Professor)
Cancer; cell cycle; DNA replication; chromatin assembly; biochemistry; yeast genetics

Tonks, Nicholas (Professor)
Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function

Trotman, Lloyd (Associate Professor)
Cancer modeling and treatment; Senescence and tumor progression; cancer visualization; PTEN regulation

Tuveson, David (Professor)
Pancreatic cancer, experimental therapeutics, diagnostics, mouse models, cancer genetics

Vakoc, Christopher (Associate Professor)
Chromatin; transcriptional regulation; acute myeloid leukemia; BET bromodomains; lysine methyltransferases

Van Aelst, Linda (Professor)
Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development and disorders

Watson, James D. (Oliver R. Grace Professor Emeritus/Chancellor Emeritus)

Wigler, Michael (Professor)
Human genetic disorders; population genetics; cancer genomics

Zhang, Lingbo (CSHL Fellow)
Normal and malignant hematopoietic progenitor/stem cells; self-renewal; myelodysplastic syndrome; cancer-related anemia; leukemia

Zheng, Hongwu (Assistant Professor)
Malignant gliomagenesis; animal modeling; stem cell renewal/differentiation; genetic and epigenetic regulation



Cold Spring Harbor Laboratory is an NCI-designated Cancer Center. As a basic research institution, CSHL does not treat patients. Information about individual cancers is available at the NCI CancerNet. Questions about CSHL's cancer research program should be directed to our Public Affairs Department.