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MZEF (Exon-Finding) Software
© 1997 Cold Spring Harbor Laboratory
MZEF is software developed by Dr. Michael Zhang at Cold Spring Harbor Laboratory that provides a new method for predicting internal coding exons in genomic DNA sequences. This computer program allows users to predict putative internal protein coding exons, adjust prior probability and to output alternative overlapping exons.
MZEF is based on a prediction algorithm using the quadratic discriminant function for multivariate statistical pattern recognition. As documented in some review articles* this methodology offers substantial improvements over existing software based on linear discriminant analysis or neural networks for analyzing both plant and animal genomes.
CSHL is making MZEF site licenses available to commercial entities for internal use. This software is available in 4 Versions, for analysis of specific types of genomic data:
· Human (see M.Q. Zhang, PNAS 94:565-568, 1997)
· Mouse
· Arabidopsis thaliana (See M.Q. Zhang, Plant Mol Biol 37:803-805, 1998)
· Schizosaccharomyces pombe (see MQ Zhang & T Chen, Yeast 14(8):701-10, 1998)
- The license fee for a site-license for a single version is $5,000
- The site-license fee for any two versions is $8,000 or any three versions is $10,000.
- For license fee for source code of a single version is $15,000
* Claverie, J-M, Computational methods for the identification of gene in vertebrate genomic sequence, Hum Mol Genet 6: 1735-1744 (1997)
Parnell L., Dedhia N, McCombie WR: A statistical analysis of the success of exon prediction algorithms, The 1997 Biotechnology Conference on the Arabidopsis Genome: From Sequence to Function, Dec 11-14, 1997 Cold Spring Harbor, NY
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