Ph.D., University of Copenhagen and the Danish Cancer Society, 2000
Tumor microenvironment; intravital imaging; tumor-associated myeloid cells; breast cancer
The Egeblad lab studies the contributions of the tumor microenvironment - in which cancer cells arise and live - to therapy responses and metastasis. Solid tumors are abnormally organized tissues that contain not only cancer cells, but also various stromal cell types and extracellular matrix, and these latter components constitute the microenvironment. Communications between the different components of the tumor influence its growth, its response to therapy, and its ability to metastasize. The lab studies the importance of such communications using mouse models of breast and pancreatic cancer. We use microscopy in tumors in live mice to determine how interactions between cancer and stromal cells or activation of specific signaling pathways influence cellular survival, proliferation and migration at the microscopic level. We use bioluminescence and small animal ultrasound to follow tumor progression and regression at the organism level. Among the tumor-associated stromal cells, our main focus is on myeloid-derived immune cells, a diverse group of cells that can enhance angiogenesis and metastasis and suppress cytotoxic immune responses against tumors. We study how different types of myeloid cells are recruited to tumors and how signals between them and cancer cells, or other immune cells, influence response to chemotherapy and metastatic spread.
Please visit Mikala's Lab home page.
Nakasone, E.S., Askautrud, H.A., Kees , T., Parks, J.-H., Plaks, V., Ewald, A.J., Fein, M., Rasch, M.G., Tan, Y.X., Qiu, J., Park, J., Sinha, P., Bissell, M., Frengen, E., Werb, Z., and Egeblad, M. 2012. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell 21: 488–503.
Engelhardt, J.J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorenson, C., Werb, Z., Egeblad, M., and Krummel, M.F. 2012. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21: 402–417.
Egeblad, M., Nakasone, E., and Werb, Z. 2010. The tumor as an organ: complex tissues that interface with the entire organism. Dev. Cell 18: 884–901.
Egeblad M., Rasch, M.G., and Weaver V.M. 2010. Dynamic interplay between the collagen scaffold and tumor evolution. Curr. Opin. Cell Biol. 22: 697–706.
Levental, K.R., Yu, H., Kass, L., Lakins, J.N., Egeblad, M., Erler J.T., Fong, S.F., Csiszar, K.L., Giaccia, A., Weninger, W., Yamauchi, M., Gasser, D.L., and Weaver, V.M. 2009. Matrix cross-linking forces tumor progression by enhancing integrin signaling. Cell 139: 891–906.