Ph.D., Dartmouth College, 2003
|To ensure that cells function normally, tens of thousands of genes must be turned on or off together. To do this, regulatory molecules - transcription factors and non-coding RNAs – simultaneously control hundreds of genes. My group studies how the resulting gene networks function and how they can be compromised in human disease.|
Human development requires the regulated activity of thousands of genes in hundreds of distinct cell types throughout life. One requirement for this process is that each cell must contain an intact, functional genome free from mutations. One type of mutation can arise  from the  activation of transposable elements (TEs). These viral-like parasites lay dormant within our genomes, but have the  capacity to hop into new genomic locations, causing mutations  as they break  the surrounding DNA sequence. Mounting evidence has implicated transposon activity in a host of human diseases, with particular evidence for TE activation in neurodegenerative diseases: Amyotrophic lateral sclerosis (ALS) and fronto-temporal dimensia (FTD).
Rozhkov, N. V. and Hammell, M. and Hannon, G. J. (2013) Multiple roles for Piwi in silencing Drosophila transposons. Genes and Development 27(4) pp. 400-412.
Li, W. H. and Jin, Y. and Prazak, L. and Hammell, M. and Dubnau, J. (2012) Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders. PLoS ONE 7(9)
Hammell, M. (2010) Computational methods to identify miRNA targets. Seminars in Cell & Developmental Biology 21(7) pp. 738-44.
Hong, X. and Hammell, M. and Ambros, V. and Cohen, S. M. (2009) Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proceedings of the National Academy of Sciences of the United States of America 106(35) pp. 15085-90.
Hammell, M. and Long, D. and Zhang, L. and Lee, A. and Carmack, C. S. and Han, M. and Ding, Y. and Ambros, V. (2008) mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nature Methods 5(9) pp. 813-9.Additional materials of the author at
CSHL Institutional Repository
2014 Rita Allen Foundation Scholar