Ph.D., Columbia University, 2008
Every gene has a job to do, but genes rarely act alone. Biologists have built models of molecular interaction networks that represent the complex relationships between thousands of different genes. I am using computational approaches to help define these relationships, work that is helping us to understand the causes of common diseases including autism, bipolar disorder, and cancer.
Ivan Iossifov focuses on the development of new methods and tools for genomic sequence analysis and for building and using molecular networks, and he applies them to specific biomedical problems. He studies the genetics of common diseases in humans using two main tools: next-generation sequencing and molecular networks representing functional relationships among genetic loci. These approaches in combination enable the kind of large-scale studies necessary for furthering our understanding of the complex etiology of disorders such as autism, bipolar disorder, and cancer.
Rodriguez-Esteban, R. & Iossifov, I. Figure and table mining for biomedical research. (2009) Bioinformatics 25: 2082–4
Liu, J., Ghanim, M., Xue, L., Brown, C. D., Iossifov, I., Angeletti, C., Hua, S., Nègre, N., Ludwig, M., Stricker, T., Al-Ahmadie, H. A., Tretiakova, M., Camp, R. L., Perera-Alberto, M., Rimm, D. L., Xu, T., Rzhetsky, A., & White, K. P. Integrated genomic analysis of the Drosophila segmentation network leads to identification of a highly specific biomarker for human kidney cancer. (2009) Science 323: 1218–22
Ivan Iossifov, Tian Zheng, Miron Baron, T. Conrad Gilliam, and Andrey Rzhetsky Genetic-linkage Mapping of Complex Hereditary Disorders to a Whole-genome Molecular-interaction Network. (2008) Genome Research
Murat Cokol, Ivan Iossifov, Raul Rodriguez-Esteban, and Andrey Rzhetsky How many scientific papers should be retracted? (2007) EMBO reports 8: 422–3
Raul Rodriguez-Esteban, Ivan Iossifov, and Andrey Rzhetsky Imitating manual curation of text-mined facts in biomedicine.(2006) PLoS Comput Biol. 2: e118