Ph.D., The University of Tokyo, 2001
The nervous system transmits information by passing chemical signals from one nerve cell to the others. This signal transmission relies on a variety of proteins to receive and transmit the chemical signals. My group studies the structure and function of neurotransmitter receptors and ion channels that regulate fundamental neuronal activities.
Hiro Furukawa’s lab studies receptor molecules involved in neurotransmission. Its members mainly focus on the structure and function of NMDA (N-methyl-d-aspartate) receptors—ion
channels that mediate excitatory transmission. Dysfunctional NMDA receptors cause neurological disorders and diseases including Alzheimer’s disease, Parkinson’s disease, schizophrenia, depression, and stroke-related ischemic injuries. The Furukawa lab is working to solve the threedimensional structure of the very large NMDA receptor by dividing it into several domains. They seek to understand the pharmacological specificity of neurotransmitter ligands and allosteric modulators in different subtypes of NMDA receptors at the molecular level. Toward this end, they use cutting-edge techniques in X-ray crystallography to obtain crystal structures of the NMDA receptor domains and validate structure-based functional hypotheses by a combination of biophysical techniques including electrophysiology, fluorescence analysis, isothermal titration calorimetry, and analytical centrifugation. Crystal structures of NMDA receptors serve as a blueprint for creating and improving the design of therapeutic compounds with minimal side effects for treating neurological disorders and diseases. During the last several years, the team discovered and mapped several regulatory sites in specific classes of NMDA receptors, progress that now opens the way to the development of a new potential class of drugs to modulate the receptor activity.
Karakas, E. and Furukawa, H. (2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science 344(6187) pp. 992-7.
Jespersen, A. and Tajima, N. and Fernandez-Cuervo, G. and Garnier-Amblard, E. C. and Furukawa, H. (2014) Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron 81(2) pp. 366-78.
Karakas, E. and Simorowski, N. and Furukawa, H. (2011) Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature 475(7355) pp. 249- U170.
Vance, K. M. and Simorowski, N. and Traynelis, S. F. and Furukawa, H. (2011) Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature Communications 2
Karakas, E. and Simorowski, N. and Furukawa, H. (2009) Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Embo Journal 28(24) pp. 3910-3920.Additional materials of the author at
CSHL Institutional Repository
CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit