4 CSHL neuroscientists win NARSAD Young Investigator awards to study autism, schizophrenia




Cold Spring Harbor, NY –
Four early-career neuroscientists at Cold Spring Harbor Laboratory (CSHL) have been awarded prestigious NARSAD Young Investigator grants.  The announcement was made by the Great Neck, N.Y.-based Brain and Behavior Research Foundation (BBRF).

The four are all postdoctoral researchers, and are among 200 awardees chosen from among 1199 applicants worldwide.  The two-year, $60,000 NARSAD grant award is highly coveted within neuroscience circles, in part as a mark of recognition for doing cutting-edge research as recognized by BBRF’s 138-member scientific council; and as a means of facilitating the transition for young scientists to ultimately work in laboratories they themselves direct.

sahrensSandra Ahrens, Ph.D. Bruce Stillman, Ph.D., the President and CEO of CSHL, extended his warm congratulations to the four. “On behalf of the entire faculty, let me say that we are proud of you, individually, and pleased that through your projects, the goal of our basic research program in neuroscience of understanding the biology underlying devastating disorders including schizophrenia and autism has been given an important boost."

Dr. Jeffrey Borenstein, BBRF president and CEO, explains that the NARSAD Young Investigator Grants “enable early-career scientists to garner pilot data for innovative ideas before they have ‘proof-of-concept’ for their work. After our initial funding, they usually go on to receive sustained grant support from other sources that has proven to equal as much as 50 times the original NARSAD grant amount. Our grants offer the first critical backing of their work.”

guyhorevGuy Horev, Ph.D.Three of the four CSHL grant winners are studying autism and autism spectrum disorder (ASD); one is conducting research on schizophrenia. They are:

Sandra  Ahrens, Ph.D., in the lab of Associate Professor Bo Li, will study the role of a brain circuit called the thalamic reticular nucleus circuit and its dysfunction in a genetically engineered mouse model of schizophrenia. The thalamic reticular nucleus is thought to play a critical role in sensory processing and in cognitive functions such as attention. Deficits in attention is a core feature of schizophrenia.

Guy Horev, Ph.D., in the lab of Professor Alea Mills, will assess brain development in mouse embryos with a genetic deletion on the chromosomal 16p11.2 region, a deletion that occurs in patients with autism, so as to pinpoint yongsookimYongsoo Kim, Ph.D. the genes that lead to autism-like impairment and establish a cellular assay for impairment and, ultimately, to see if rescuing the developmental impairment will correct the behavioral impairments.

Yongsoo Kim, Ph.D., in the laboratory of Associate Professor Pavel Osten, will explore aspects of a finding that intranasal oxytocin can improve social behavior in autism. The study will determine the physiological mechanisms of intranasal oxytocin in an animal model of autism, describe what brain regions respond, and how it alters brain  activity in  response  to  social stimulation that leads to the improvement in social behavior.

Keerthi Krishnan, Ph.D.,in the lab of Professor Z. Josh Huang, seeks to unravel the pathogenesis of Rett syndrome, an autism spectrum disorder, caused by mutations in methyl-CpG-binding
keerthikrishnanKeerthi Krishnan, Ph.D. protein 2 (MeCP2). The study will use advanced genomic methods in a mouse model to trace molecular changes in a brain region-specific, cell type-specific manner during early development, and thus begin to unravel the complex genetic architecture of Rett Syndrome.

About the Brain and Behavior Research Foundation

Since 1987, the Foundation has invested over $300 million in research to identify causes, improve treatments and develop prevention strategies for a broad range of psychiatric disorders, including depression, schizophrenia, autism, and bipolar, anxiety, post-traumatic stress, attention-deficit hyperactivity and obsessive-compulsive disorders.  All overhead costs for the NARSAD Grants programs and operational expenses of the Foundation are underwritten by two family foundations:
100% of all donor contributions for research are invested in NARSAD Grants. For more information
visit bbrfoundation.org

About Cold Spring Harbor Laboratory

Founded in 1890, Cold Spring Harbor Laboratory (CSHL) has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. CSHL is ranked number one in the world by Thomson Reuters for the impact of its research in molecular biology and genetics. The Laboratory has been home to eight Nobel Prize winners. Today, CSHL's multidisciplinary scientific community is more than 600 researchers and technicians strong and its Meetings & Courses program hosts more than 12,000 scientists from around the world each year to its Long Island campus and its China center. Tens of thousands more benefit from the research, reviews, and ideas published in journals and books distributed internationally by CSHL Press. The Laboratory's education arm also includes a graduate school and programs for middle and high school students and teachers. CSHL is a private, not-for-profit institution on the north shore of Long Island. For more information, visit www.cshl.edu.
 
Written by: Peter Tarr, Senior Science Writer | tarr@cshl.edu | 516-367-8455