For his research on the p53 tumor suppressor gene, Scott Lowe, deputy director of the Cold Spring Harbor Laboratory Cancer Center, is the recipient of the fourth American Association for Cancer Research (AACR)-National Foundation for Cancer Research (NFCR) Professorship in Basic Cancer Research.
“The AACR Laboratory Research Awards Committee and the AACR Board of Directors wish to honor you for your stunning discoveries of p53 mutations,” said Dr. Margaret Foti, chief executive officer of AACR, in her letter to Lowe. “Your intense work on dissecting the p53 pathway, including important proteins such as p19, Arf, Apaf-1, and capase-9, is specifically lauded as highly innovative in revealing their role in apoptosis. Your accomplishments to date are evidence of your potential for further stellar work in cancer research.”
p53 acts at a variety of levels to protect against cancer. Using a genetic approach, Lowe’s laboratory is interested in how oncogenes (cancer-causing genes) signal p53 and the factors that influence if it will prevent the cancer from spreading or if its malfunction will allow the cancer to continue.
The AACR and the National Foundation for Cancer Research established this Professorship in 2000 to recognize one senior scientist at the level of Associate Professor or Professor who is currently engaged in an active research career anywhere in the world and who has demonstrated extraordinary achievement in basic cancer research. It is awarded to an individual who shows promise for continued substantive contributions to basic cancer research and is intended to foster the research productivity of the recipient by enabling him or her to devote more time to basic research.
The award is in honor of Franklin and Tamara Salisbury, who are best known in the scientific research community for having founded the NFCR in 1973. Franklin, an attorney and entrepreneur, and Tamara, a research chemist at NCI and a project officer in the chemistry branch of the Office of Naval Research, were inspired by the work of Albert Szent-Gyorgyi, who received the Nobel Prize for his discovery of Vitamin C. This led them to found the NFCR based on a commitment to support basic science cancer research in the laboratory and sharing the best ideas of the best minds around the world.
The American Association for Cancer Research (AACR), a scientific society of over 21,000 laboratory and clinical cancer researchers, was founded in 1907 to facilitate communication and dissemination of knowledge among scientists and others dedicated to the cancer problem; to foster research in cancer and related biomedical sciences; to encourage presentation and discussion of new and important observations in the field; to foster public education, science education, and training; and to advance the understanding of cancer etiology, prevention, diagnosis, and treatment throughout the world.
Since its founding in 1973, the National Foundation for Cancer Research has spent more than $200 million funding basic science cancer research and education focused on understanding how and why cells become cancerous. This worldwide "laboratory without walls" assembles the intellectual power to achieve one of medicine's greatest goals: a cure for cancer-all types of cancer. Prevention, new treatments, and a cure depend on understanding cancer's genetic origins; NFCR is dedicated to funding scientists who are discovering cancer's molecular mysteries and translating these discoveries into therapies that hold the only real hope for curing cancer. NFCR is Research for a Cure. For more information, please visit NFCR's website at www.NFCR.org or call (800) 321-CURE
Cold Spring Harbor Laboratory is a private, non-profit basic research institution. Under the leadership of Dr. Bruce Stillman, a member of the National Academy of Sciences and a Fellow of the Royal Society (London), 308 scientists at the Laboratory conduct groundbreaking research in cancer, neurobiology, plant genetics, and bioinformatics. For more information, visit www.cshl.edu.